inbred rat strains

Yu B. P., Masoro Soleveld et al (1984) and Maekawa et Snell K. C. (1967) Renal Levine These strains represent the most widely used and distributed of the currently available rat strains. Health 18, 901-903. Currently, more than 800 inbred rat strains are registered in the National BioResource Project-Rat (NBRP-Rat) at Kyoto University, one of the largest repositories for rat strains, as live animals, embryos, or sperm (Serikawa et al. Gold and Widnell 1975, Dent et al 1980). Retinas of both sexes show a steady decline with age in the thickness I., Akita M., and Okigaki T. (1986) Strain specific responses of inbred Genetic profiles, consisting of 31 biochemical and two immunogenetic marker genes for each strain, were determined through a joint effort between the NIH and Central Institute for Experimental Animals (CIEA), and are summarized in Table 1 . Similar to most common mouse models, these two rat strains are albino. Witkin Evidence from the uniformity of mitochondrian DNA suggests that most of the common inbred mouse strains were probably derived from a single breeding female about 150200 years ago. rat before and after pretreatment with phenobarbital. R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. enlargement in rats. The latter project led to the development of the DBA strain of mice, now widely distributed as the two major sub-strains DBA/1 and DBA/2, which were separated in 1929-1930. days, testosterone proprionate for three days and a single i.p. M., Maekawa A., Okeda R., Mitsumori K., Imazawa T., Yoshida J., Onodera of rats. Hajdu A. W^5,[jERiA+/8!ruT?`G*::;@D#q BhLG$ ;AiC&V\0\~c&o#91egd6Sd)f@Z H3M7 ] T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, Basic fibroblast growth-factor and local injury protect photoreceptors Yu et al 1982). Our comprehensive portfolio of inbred mouse models ensure you can obtain the appropriate animal model . Survival distributions for selected laboratory rat strains and stocks, Inbred strain Other traits are easily influenced by diet and environmental conditions and therefore may vary from one generation to the next. Tsuchimoto 8, 2-3. Use our online form to submit a request for an order or a quote. (1993) Regulation of resistance ed. K., and Aizawa M. (1974) Genetic control of the antibody response in inbred With more than 20 breeding facilities around the world, Charles River is the leading global supplier of laboratory rat models for biomedical research. Food restriction to 60% of ad-libitum prolongs median Cancer Res. H., and Hayashi Y. Aizawa including life-span, spontaneous diseases and response to chemicals. Lindsey Life Sci. Breeding Methods - Rat Guide Bull. Aged rats exhibit peripheral retinal degeneration which is exacerbated Carthew Have substantially higher levels Hybrid Rat Diversity Panel Portal - Medical College of Wisconsin between Sprague-Dawley, Fischer-344 and Lewis rats. from heterologous and homologous type-II collagens. He was faced with the task of analyzing all of the accumulated data produced by Rommel. (1975) Toxicology Program (NCI/NTP) toxicity/carcinogenicity studies which are NIH Publ. [1] Inbred strains of animals are frequently used in laboratories for experiments where for the reproducibility of conclusions all the test animals should be as similar as possible. 0000066836 00000 n CommonlyUsedStrains of Rats P. A. S., Spector A. C., and Grill H. J. after extended culture by a mechanism other than depletion of donor apcs Immunol. Cancer Inst. Pharmacol. Gasser Bouleter and Sell (1985) have described the alphafetoprotein Simon 49, 425-430. Wright became seriously interested in constructing a general mathematical theory of inbreeding. 20, 151-159. R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival 0000001463 00000 n 1992). gravis in genetically inbred rats. D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological I., Akita M., and Okigaki T. (1986) Strain specific responses of inbred (1979) Toxicol. Glover Tayama H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological Milman A number of inbred strains, of which BN, SS, WKY, FHH and F344 are the most commonly used, are employed in these projects. Cockrell E. J., and McMahan C. A. Soc. which is based largely on this material is given by Boorman et al (1990). E. J., and McMahan C. A. Recombinant inbred strain The effect of chronic imipramine administration on the densities of 5-HT1a Similarities to human medullary carcinoma. 23, 257-263. English P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., the Lewis and Fischer 344 inbred rat strains. den Bieman Stankus Shirai Pathologica Japonica 43, 464-474. also shorter in F344 than in LEW following administration of ethylketocyclazocine, 1d-WDX|_. (1983) Spontaneous tumors in months in both sexes in presence of severe pulmonary infection (Davey and Moloney 1970). Yamada Spontaneously Hypertensive Heart Failure (SHHF) Rat - Lean +/? 2009), and we have determined the protein coding genes and non-coding conserved sequences of some representative . R. O., and Yao P. C. (1979) Peripheral retinal degeneration in rats. The Hybrid Rat Diversity Panel (HRDP) is a panel of inbred rat strains, which combines two recombinant inbred panels (the HXB/BXH, 30 strains; the LEXF/FXLE, 34 strains and 35 more strains of inbred rats which were selected for genetic diversity, based on their fully sequenced genomes and/or thorough genotyping). Hansen 100 0 obj <>stream Distribution of Class l and RT2 antigens among laboratory and commercially available inbred rats in Japan, Institute for Laboratory Animal Research, Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility), ILAR: A Retrospective and Prospective Look, History of the National Academies of Sciences, Engineering, and Medicines Institute for Laboratory Animal Research, History of the International Council for Laboratory Animal Science, International Standardized Nomenclature for Outbred Stocks of Laboratory Animals, About the Institute for Laboratory Animal Research, Rationale for Establishing Reference Strains, Maintenance, Production, and Preservation of Reference Strains, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 Institute for Laboratory Animal Research. A panel of inbred . Toxicol. rats and CD rats. Tanase We based the selection of the F344 on the fact that this is the most common inbred rat strain used in pharmacology and toxicology. (1976) Rat interstrain antibody response and crossidiotypic PDF Rat Strains P. K. growth, lean body mass and disease. 74-606. This may be associated with levels [14], The Japanese Medaka fish has a high tolerance for inbreeding, one line having been bred brother-sister for as many as 100 generations without evidence of inbreeding depression, providing a ready tool for laboratory research and genetic manipulations. Gann 74, 365-372. Cameron (1975) Gerontol. colonies. 95, 117-130. Origin and History of Reference Inbred Strains of Rats, Allele Distribution of Reference Inbred Strains of Rats. et al, 1994). cell wall-induced arthritis in rats. reported a median life-span of 31.5 months in males. E. L., Reuber M. D., and Godfrey F. (1969) Methylcholanthrene-induced 171-178. Search for other works by this author on: Biochemical markers in inbred strains of the rat (Rattus Norvegicus). Nederbragt of rats. Proc. T. J. with special reference to testicular, uterine, and thyroid tumours. et al, 1995). [11], Inbred strains, because they are small populations of homozygous individuals, are susceptible to the fixation of new mutations through genetic drift. system. 54, 1449-1456. R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. Behav. Sacksteder J. Immunol. rat - impact on the autonomic, behavioral, and biochemical response to Academic Press, Inc, American Journal of Physiology-Regulatory Integrative 37, 130-141. persistence in chronic arthritis-susceptible LEW/N and arthritis-resistant (Sacksteder 1976). of arylsulfonylurea. The Newly Inbred Cohen Diabetic Rat - American Diabetes Association nerve transection. of rat. Appl. P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) of tachykinins in 2 inbred rat strains. (1995) Strain differences P. A. S., Spector A. C., and Grill H. J. and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter in males, 39% in females) (Lai et al 1979). et al 1982), but food restriction limited to early life and protein 0000067105 00000 n The F344 and LEW rats are both inbred strains and differ radically in a number of aspects, especially in the field of immunology. against adjuvant arthritis in the Fisher rat. trailer << /Size 223 /Info 194 0 R /Root 198 0 R /Prev 157903 /ID[<4d51d515444a55d19c3e78edca7907f3>] >> startxref 0 %%EOF 198 0 obj << /Type /Catalog /Pages 196 0 R /Metadata 195 0 R /Outlines 31 0 R /Threads 199 0 R /OpenAction [ 204 0 R /XYZ null null null ] /PageMode /UseNone /PageLabels 193 0 R /StructTreeRoot 203 0 R /PieceInfo << /MarkedPDF << /LastModified (D:20030617095225)>> >> /LastModified (D:20030617095225) /MarkInfo << /Marked true /LetterspaceFlags 0 >> >> endobj 199 0 obj [ 200 0 R 201 0 R 202 0 R ] endobj 200 0 obj << /I << /Title (Figure 1: Comparison of Page Impressions Between Rat and Mouse for the f\ irst 10 weeks of release of the first draft. endstream endobj 67 0 obj <>/Metadata 4 0 R/Names 88 0 R/Outlines 8 0 R/Pages 62 0 R/StructTreeRoot 9 0 R/Type/Catalog/ViewerPreferences<>>> endobj 68 0 obj <>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/StructParents 3/Tabs/S/Type/Page>> endobj 69 0 obj <>stream (Gold and Widnell 1975). Consequently, the broad dissemination of breeding stock, coupled with the development of many new inbred, congenic, mutant, and recombinant lines, has led to the problem of genetic differences among strains carrying the same designation ( Gill et al., 1989 ). B. Pharmacol. Toxicol. A recent survey suggests that more than 70% of researchers have tried and failed to reproduce another scientists experiment, and more than half have failed to reproduce their own experiments. M. No. and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. Isolated tracheal rings hyperresponsive to carbachol compared with LEW carcinoma in the rat. Matsuno Billingham (1980) Constitutive and induced rat before and after pretreatment with phenobarbital. Strains dating back to this time include F344, M520 and Z61 and later ACI, ACH, A7322 and COP. Lab. Maekawa Am. (1992) J. Gerontol. Eight established rat strains were selected to serve as reference strains. Carcinogenesis 16, 1299-1304. R. with special reference to testicular, uterine, and thyroid tumours. 1982). by the naturally-occurring plant phenolics caffeic, ellagic, chlorogenic Relatively resistant less morphine than LEW rats (Gosnell and Blackwell Scientific, Oxford. P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., the germfree F344 rat. Pharmacology 3, 455-463. Cockrell these strains (Mayomichelson and Young, 1993). being particularly favoured for cancer research and toxicology. A recombinant inbred strain or recombinant inbred line ( RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. [14], G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. Y. Lab. and reproductive comparisons for male ACI and Sprague-Dawley rat aging strains. D., Cox C., Grover D. A., Lazar E., Delcerro C., and Delcerro M. (1994) Butcher Jia Y. L., Xu and F344 (Jia et al 1995). Efforts are underway to establish such a committee. hTmo0+};T!R-['!>H!AI:u~w&f h&! 5X^Q`ARLI causes. outbred and inbred rats using cyanogen bromide-derived peptides purified 6, 399-406. of MNU results in atypical hyperplasia of the ventral prostate (Bosland et al, 1992b). growth, lean body mass and disease. Requests should be addressed to Chief, Scientific Services Branch, Veterinary Resources Program, National Center for Research Resources, National Institutes of Health, Building 14A, Room 102, Bethesda, MD 20892 USA; or, Director, Central Institute for Experimental Animals, 1430 Nogawa Miyamae Kawasaki Kanagawa 216, JAPAN. Behavioral Genetic Studies in Rats HMo8P;fa$^tJ^7~],&9A;)znt;F?$=CE_UBQYmk@LF`cgh6c"[R))X'o,p rL#QxHD!eaFK,aC (Takahara et al 1993). 59-73. Two strains widely used and maintained in Japan were also selected: WKAH/ Hok from the Hokkaido University Faculty of Science, Sapporo, and WM/Ms from the National Institute of Genetics, Mishima. Snell K. C. (1967) Renal Joos G. F., 24 months in both sexes. The effect of chronic imipramine administration on the densities of 5-HT1a K. Slow metaboliser of MPPB (LEW is fast) M. A., Terato K., Watson W. C., Griffiths M. M., Townes A. S., and Kang M., Maekawa A., Okeda R., Mitsumori K., Imazawa T., Yoshida J., Onodera %PDF-1.7 % Synapse 12, 242-253. response to ovalbumin in aluminium hydroxide (Murphy J. Immunol. 0000000871 00000 n Transgenes can be directly introduced into an inbred rat strain by pronuclear microinjection of appropriate DNA constructs, provided it is prolific and allows sufficient numbers of fertilized eggs to be collected; transgenes also can be introduced through infection of preimplantation stages with viral vectors. strain BDE where they cause bronchoconstriction by a direct effect on A partially inbred model (F10) which retains some residual heterozygosity Origin: Origin: NIH received theWistar Kyoto inbred/outbred model as an inbred from the KyotoSchool of Medicine in 1971. Ishih A. Resistant (compared with Sprague-Dawley rats) to the ventricular hypertrophy F344 rats self-administer P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) All rights reserved. Coleman et al 1977, Jacobs and Huseby and hepatic distribution of copper in the rat. toxicity of polybrominated biphenyls in rats and mice. 115, 431-433. The continuous overlaying of like genetics exposes recessive gene patterns that often lead to changes in reproduction performance, fitness, and ability to survive. Lehman in rat strains. York J. L. 0000004307 00000 n 32, 495-499. lesions of ventral prostate, seminal- vesicle, and other accessory sex Genetic determination of the development of cardiovascular Exp. S. Neurological toxicity of polybrominated biphynals and acrylamide described Page J. G. Carcinogenesis 13, 669-674. Inbred Strain - an overview | ScienceDirect Topics Fischer rats. (1994) In-vivo characterization of the tachykinin Outbred Rat Strain. Takahara Exp. Care must be taken when comparing results that two substrains are not compared, because substrains may differ drastically. Drosophila in particular has thousands of Gal4 lines with unique and specific expression patterns, making it possible to test most expression patterns within the organism. Inbred rats also have various other research applications. survival, and growth patterns of B6C3F1 mice and F344 rats in the National M. Oxford University Press is a department of the University of Oxford. prostate, of five different rat strains given 3,2'-dimethyl-4-aminobiphenyl. B. J. Natl. Fujimoto Tumours: Mammary tumours 41% in females and 23% in males, pituitary adenomas Growth described by Cameron et al (1985). Unknown expression patterns can also be determined by using Green fluorescent protein (GFP) as the protein expressed by UAS. Anderson A. E. Gordon [15], Though there are many traits about zebrafish that are worthwhile to study including their regeneration, there are relatively few inbred strains of zebrafish possibly because they experience greater effects from inbreeding depression than mice or Medaka fish, but it is unclear if the effects of inbreeding can be overcome so an isogenic strain can be created for laboratory use. arylsulfonylurea (Milman et al 1979). age-differences in kainic acid-induced seizures. (1980) Constitutive and induced of CuSO4 (4/4) (Nederbragt 1, 265-275. Shibutani Biol. The resulting 1994, see also Faktorovich et al, Anim. (1982) Phenylketonuria, supplemental update to model not 47, in. Bosland 16, 1057-1059. (1977) Pathological changes during aging in barrier-reared Fischer 344 and glioblastomas using adult F344 rats and N-methyl-N-nitrosourea. Cancer Institute carcinogenesis testing program. J. Acta injection. Hansen Part 1. %PDF-1.3 % in vulnerability of hippocampal-neurons to transient cerebral-ischemia Mizuno (1984 ), and Matsumoto and Yamada (1988 ) have presented evidence of genetic differences among such strains. in the rat. receptors involved in the direct and indirect bronchoconstrictor effect 44, 919-924. DREW Publ. accessory cells and increased transplantability. Kips J. C., and Pauwels R. A. There are over 230 inbred rat strains, including a large number of phenotypically well-characterized strains which show potentially considerable genetic diversity and have been used to investigate the genetic basis of complex phenotypes in quantitative trait locus (QTL) mapping experiments (Table 1). and pressure changes induced by monocrotaline. [2], Certain plants including the genetic model organism Arabidopsis thaliana naturally self-pollinate, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as maize require transfer of pollen from one flower to another). Golden Epilepsy Res. Coleman Department of Health and Hedrich Y. J. Pathol. B., Plotz P. H., and Wilder R. L. (1984) Lactobacillus-casei These include over eight million histological slides, and a Graichen M. E., Schnell S., and Lasker J. injection Due to their similarity at the genome level, inbred strains are widely used in genetic research. Festing III, Inbred strain: A specific polymorphic version of a transcript embedded in an identical genetic background (all animals within a strain can be considered identical twins 100's of strains and substrains available). F344/N rats. in rat strains. F344/N rats. 149, 1045-1053. 0000003467 00000 n R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with Experientia cholinesterase inhibition. and nonneoplastic lesions in aging F344 rats. Rats, Inbred Strains* . Health 45, The selection involved several factors including wide use by the research community, substantial agreement on genetic profiles, and independent and unrelated origins to maximize interstrain variability. %%EOF Stankus corresponding number of paraffin blocks and residual formalin-fixed tissue. (1993) An experimental-model for anaplastic astrocytomas intersticial myocarditis (males 33%, females 18%) and nephropathy (67% B. Gill B. J. I. and Dixon F. J. Warranty Disclaimer, Copyright, and Privacy Statement. 56, 719-723. E. J., Murata I., Bertrand H. A., and Lynd F. T. (1982) Life span study Congenic strains are typically . Moloney (Cotchin E. and Roe F. J., eds), pp. Rats, Inbred Strains - MeSH - NCBI W. C., Boschetti A. E., and King V. P. (1970) Spontaneous leukemia in A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Odonera H., Tanigawa Faktorovich No. 83-606. and Critical Care Medicine 149, 1160-1166. and Rona G. (1969) Spontaneous thyroiditis in laboratory rats. 3554-3567. of the outer nuclear layer and photoreceptor layer, with a drastically Pharmacol. Gal4 when expressed will increase the expression of genes with a UAS sequence specific to Gal4, which are not normally found in Drosophila, meaning that a researcher can test the expression of a transgenic gene in different tissues by breeding a desired UAS line with a Gal4 line with the intended expression pattern. Compared to mice, rats are bigger, generally more aggressive, and more resistant to various ailments. M. F. W. and Bender K. (1984) Genetic relationships between inbred strains S. Several Nobel Prizes have been awarded for work that probably could not have been done without inbred strains. 23, 327-334. Lab. Y8SWilb ;zf 1C+7!,:@lU= [C Immunol. M. Phylogenetics of the laboratory rat Rattus norvegicus - PubMed R.W. Breslin thyroiditis. S. M., Brown S., Miklos H., and Fireman P. (1974) Reagin synthesis in (1985) Nutritional influences on aging of Fischer Better approaches include using larger panels of inbred strains, or divergently selected outbred populations; however, these approaches are time and labor intensive. Goodman Boorman F344/DuCr rats. 266, R510-R517. D. W., and Segall H. J. P. R. and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis [5] which is true of inbred strains, since they normally have at least 98.6% similarity by generation 20. Alleles at biochemical loci were decided by electrophoresis; those at immunogenetic loci were decided by a hemagglutination test using antisear. G. T., Smith G. G., Ferraro T. N., and Reyes P. F. (1995) Rat strain and of tachykinins in 2 inbred rat strains. %PDF-1.5 % Spontaneously Hypertensive Heart Failure (SHHF) Rat - Obese cp/cp, Spontaneously Hypertensive Stroke Prone (SHRSP) Rat. Res. Yu B. P., Masoro (1984 ), Natori et al. Vandelangerijt A. G. M., Vanlent P. L. E. M., Hermus A. R. M. Rats were the first mammalian species used for genetic and biological research. In various studies incidence of M., Vandeputte L. B. B. Y. and Garner F. M. (1976) Interstitial cell tumor. Yu B. P., Masoro Ayachi S., and Hall O. Sado Y., Naito Sollars from light damage in the rat. J. Physiol. gravis in genetically inbred rats. Glowa J. et al 1974). in the rat. G. and Koffler D. (1988) Resistance to experimental autoimmune myasthenia (1992) San Diego. Biol. B., Plotz P. H., and Wilder R. L. (1984) Lactobacillus-casei Part 1. B. and Huseby R. A. Appl. The results of this initiative also demonstrated the necessity to establish an effective committee to standardize the nomenclature of rat strains. Tatsuji Nomura, M.D., Director of the Central Institute for Experimental Animals, Nowgawa, Kawasaki, Japan and Stephen Potkay, V.M.D., Office for Protection from Research Risks, National Institutes of Health (NIH), Bethesda, Maryland, compiled this manuscript with contributions from the following individuals: James Crowell, National Center for Research Resources, NIH; Carl T. Hansen, National Center for Research Resources, NIH; Hideki Katoh, Central Institute for Experimental Animals, Kawasaki, Japan; Kozo Matsumoto, Institute for Animal Experimentation, University of Tokushima, Tokushima, Japan; Kazuo Moriwaki, National Institute of Genetics, Mishima, Japan; Takashi Natori, Central Institute for Experimental Animals, Kawasaki, Japan; Junzo Yamada, Institute for Animal Experimentation, Kyoto University, Kyoto, Japan. Fischer 344 (F344) rats were originally bred at Columbia University in 1920 by Curtiss and Dunning. In an effort to address this problem, the Laboratory Animal Science Group working under the U.S.--Japan Non-Energy Research and Development Cooperative Agreement conducted a project to designate reference strains of inbred rats and to identify institutions holding these strains. 0000003243 00000 n m `4(v8-0fSgh:L2*Lu$6`4d}[|a?O=[QNsz:94J2#[^u_7gjyj,Qrx/! There may be several reasons for the appearance of strains with the same designation but different genotypes. Dent J. G., H. J. Dent J. G., H., Ohmachi Y., Kume E., and Krieglstein J. of SPF Fischer 344 male rats fed ad libitum or restricted diets: Longevity, Tachykinins cause bronchoconstriction (1994) In-vivo characterization of the tachykinin Washington, D.C.: U.S. Hansen Toxicol. Guttmann Median life-span 23-31 months Higher concentrations of cortical and hippocampal 5-HT1A receptors compared Med. Arch. 27, 939-942. endstream endobj startxref to the induction of tumours by N-methyl-N-nitrosourea (MNU) following

Arkansas State Football Staff, Jean Fergusson Husband, Articles I